Entry Detail



General Information

Database ID:exR0428748
RNA Name:ACADM
RNA Type:mRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):75724347End Site(bp):75787575
External Links:ENSG00000117054



Disease Information

Disease Name:Pediatric TB meningitis
Disease Category:Infections
MeSH ID:D014390
Type:Diseases Category/Infections
Alias:Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides



Expression Detail

GEO ID:GSE122377
Description:Tuberculous Meningitis in Pediatric Patients [CSF]
Experimental Design:Disease Sample Source
Case Disease Type:Pediatric TB meningitis
Case Disease SubType:NA
Case Sample:Pediatric TB meningitis
Control Sample:Lumbar Puncture Cerebrospinal Fluid
Number of Case:12
Number of Control:12
Number of Samples:24





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DBN1
chr5
177456608
177474401
-
HMGA1
chr6
34236873
34246231
+
ARID5A
chr2
96536743
96552634
+
RPN2
chr20
37178410
37241619
+
HACD3
chr15
65530418
65578349
+
ITGB3BP
chr1
63440770
63593721
-
HYOU1
chr11
119044188
119057227
-
SLC35G1
chr10
93893973
93956062
+
RBMXL1
chr1
88979456
88992960
-
DTX4
chr11
59171430
59208588
+
FOXN2
chr2
48314637
48379295
+
PNN
chr14
39175183
39183220
+
BUB1B
chr15
40161023
40221136
+
DDX39B
chr6
31530219
31542448
-
GDI2
chr10
5765223
5842132
-
FTL
chr19
48965309
48966879
+
PKM
chr15
72199029
72231822
-
SRRM1
chr1
24631716
24673281
+
EXOSC8
chr13
36998816
37009614
+
DHX8
chr17
43483865
43610338
+
TRPC4
chr13
37636636
37870425
-
POLDIP3
chr22
42583721
42614962
-
RPL30
chr8
98024851
98046469
-
COA7
chr1
52684449
52698347
-
DNMT3B
chr20
32762385
32809356
+
ATP6V1G2-DDX39B
chr6
31530219
31546608
-
RPS24
chr10
78033760
78056813
+
NR1H2
chr19
50329653
50383388
+
NCOA4
chr10
46005088
46030714
-
XPO1
chr2
61477849
61538626
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004812.2
chr12
120116907
120119000
+
AC009948.2
chr2
178548884
178550681
+
AC069287.1
chr11
112967
125927
-
AL831711.1
chr1
161433444
161440996
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:31434901
Title:Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Author:Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ
Journal:Nat Commun. 2019 Aug 21;10(1):3767.
Description:Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.