Entry Detail



General Information

Database ID:exR0428753
RNA Name:ACAP1
RNA Type:mRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):7336529End Site(bp):7351477
External Links:ENSG00000072818



Disease Information

Disease Name:Pediatric TB meningitis
Disease Category:Infections
MeSH ID:D014390
Type:Diseases Category/Infections
Alias:Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides



Expression Detail

GEO ID:GSE122377
Description:Tuberculous Meningitis in Pediatric Patients [CSF]
Experimental Design:Disease Sample Source
Case Disease Type:Pediatric TB meningitis
Case Disease SubType:NA
Case Sample:Pediatric TB meningitis
Control Sample:Lumbar Puncture Cerebrospinal Fluid
Number of Case:12
Number of Control:12
Number of Samples:24





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HLA-DRA
chr6
32439878
32445046
+
FOXH1
chr8
144473412
144475849
-
ZNF449
chrX
135344796
135363413
+
MIF
chr22
23894383
23895227
+
KDF1
chr1
26949562
26960468
-
SQSTM1
chr5
179806398
179838078
+
PFN1
chr17
4945652
4949061
-
CD74
chr5
150400041
150412929
-
RGS10
chr10
119499817
119542719
-
TUBB
chr6
30720352
30725426
+
ISG15
chr1
1001138
1014540
+
C20orf204
chr20
64034344
64039962
+
AL133352.1
chr10
100505628
100529881
-
DHX16
chr6
30653119
30673006
-
AP002990.1
chr11
62559603
62591531
-
UGCG
chr9
111896814
111935369
+
DNAJC30
chr7
73680918
73683453
-
ACTG1
chr17
81509971
81523847
-
VPS53
chr17
508668
721717
-
HLA-DMA
chr6
32948613
32969094
-
CDC25B
chr20
3786772
3806121
+
RCC1
chr1
28505943
28539300
+
YME1L1
chr10
27110112
27155266
-
REEP3
chr10
63521401
63625128
+
CD70
chr19
6583183
6604103
-
ZNF593
chr1
26169908
26170873
+
NSMF
chr9
137447573
137459334
-
EXOC3
chr5
443175
471937
+
ZNF761
chr19
53445001
53458261
+
APH1A
chr1
150265399
150269580
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC139149.1
chr17
81514047
81527776
+
LINC01184
chr5
127939152
128083172
-
SNHG3
chr1
28505980
28510892
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:31434901
Title:Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Author:Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ
Journal:Nat Commun. 2019 Aug 21;10(1):3767.
Description:Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.