exRNAdisease

Entry Detail

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General Information

Database ID: exR0428756 RNA Name: ACAT1 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 108116695 End Site(bp): 108147603 External Links: ENSG00000075239

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP2A2 chr12 110280756 110351093 + MTRNR2L8 chr11 10507894 10509186 - TRIP10 chr19 6737925 6751530 + NPEPPS chr17 47522942 47623276 + DAPK1 chr9 87497228 87708634 + PSMB5 chr14 23016543 23035230 - CCDC102A chr16 57512181 57536571 - FZD3 chr8 28494205 28574267 + NCAM1 chr11 112961247 113278436 + PRDX4 chrX 23664262 23686397 + PSMD10 chrX 108084207 108091549 - PGK1 chrX 77910739 78129295 + HSP90AB1 chr6 44246166 44253888 + NPIPB2 chr16 11927259 11976643 - TXNRD1 chr12 104215779 104350307 + MRPL47 chr3 179588285 179604649 - AC010422.3 chr19 12643831 12648397 - GHITM chr10 84139509 84153568 + POU3F3 chr2 104853287 104858574 + RPS4X chrX 72255679 72277248 - DAP3 chr1 155687960 155739010 + EEF1A1 chr6 73515750 73523797 - GLI2 chr2 120735623 120992653 + IER3IP1 chr18 47152834 47176364 - RPLP1 chr15 69452814 69456205 + ACTG1 chr17 81509971 81523847 - IGFBP2 chr2 216632828 216664436 + NUP205 chr7 135557917 135648757 + ACTB chr7 5527148 5563784 - TXNDC16 chr14 52430596 52552522 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MIR155HG chr21 25561909 25575168 + POLR2J4 chr7 43940895 44019175 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.