exRNAdisease

Entry Detail

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General Information

Database ID: exR0429123 RNA Name: ALDH3A2 RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 19648136 End Site(bp): 19685760 External Links: ENSG00000072210

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BLM chr15 90717346 90816166 + C4orf3 chr4 119296419 119304445 - KMT2D chr12 49018975 49059774 - EIF5A chr17 7306999 7312463 + PRSS16 chr6 27247701 27256624 + NPM1 chr5 171387116 171411137 + ERGIC3 chr20 35542021 35557634 + BST2 chr19 17402939 17405630 - IQGAP1 chr15 90388242 90502239 + HMGCR chr5 75336329 75362101 + MTRNR2L3 chr20 57358447 57359498 - PEA15 chr1 160205337 160215376 + BOD1 chr5 173607145 173616659 - TUBA1A chr12 49184795 49189080 - SPCS1 chr3 52704955 52711148 + DGLUCY chr14 91060333 91225632 + GID8 chr20 62938147 62948475 + ENSA chr1 150600851 150629612 - RSL24D1 chr15 55180806 55197049 - ARPC2 chr2 218217141 218254356 + ZNF431 chr19 21142024 21196053 + MFGE8 chr15 88898683 88913381 - MIF chr22 23894383 23895227 + MPC2 chr1 167916675 167937072 - TNFRSF14 chr1 2555639 2565382 + SOX8 chr16 981770 986979 + PDZD8 chr10 117277274 117375440 - BCR chr22 23179704 23318037 + AK2 chr1 33007940 33080996 - AMACR chr5 33986165 34008104 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-19b-3p chr13 91351245 91351267 + hsa-miR-27a-3p chr19 13836447 13836467 - hsa-miR-27b-3p chr9 95085505 95085525 + hsa-miR-301a-3p chr17 59151149 59151171 - hsa-miR-431-5p chr14 100881026 100881046 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand SCARNA9 chr11 93721513 93721865 + SNHG16 chr17 76557764 76565348 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.