exRNAdisease

Entry Detail

---



General Information

Database ID: exR0437681 RNA Name: NUCKS1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 205712822 End Site(bp): 205750182 External Links: ENSG00000069275

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDOA chr16 30064164 30070457 + AFAP1 chr4 7758714 7939926 - AC068946.2 chr2 219209772 219222738 - AC015813.2 chr17 57989038 58007246 - AC091959.3 chr5 146203550 146339251 + ACTR3 chr2 113890063 113962596 + AC005832.4 chr12 4604944 4662643 + ACSS2 chr20 34872146 34927962 + AC120057.2 chr17 7240427 7244635 - AGPAT3 chr21 43865223 43987592 + AC092143.1 chr16 89919165 89936092 + ALDH7A1 chr5 126531200 126595362 - ABRACL chr6 139028745 139043302 + ABCC1 chr16 15949577 16143074 + AGPAT1 chr6 32168212 32178096 - AC010422.3 chr19 12643831 12648397 - AC058822.1 chr4 53377839 54295272 + AL136454.1 chr1 192716132 192716653 + AC020915.5 chr19 58228914 58315183 + ACTR1A chr10 102461881 102502712 - ADAR chr1 154582057 154628013 - AKT2 chr19 40230317 40285536 - AL121594.1 chr14 35122549 35317474 + ACSL4 chrX 109624244 109733403 - AC010463.1 chr19 17267418 17282966 + AFF4 chr5 132875395 132963634 - AGL chr1 99850361 99924023 + AIMP2 chr7 6009255 6023834 + AHSP chr16 31527900 31528803 + AC008982.1 chr19 38817471 38840178 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-671-5p chr7 151238449 151238471 + hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005005.3 chr22 31082156 31083565 - AC005899.4 chr17 32328441 32329395 + AC012368.1 chr2 64143239 64252859 + AC015522.1 chr8 83912713 84142463 + AC022784.3 chr8 9255349 9260295 - AC069281.2 chr7 100572232 100578700 - AC132217.1 chr11 2129121 2129964 - AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.