exRNAdisease

Entry Detail

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General Information

Database ID: exR0438412 RNA Name: PHB2 RNA Type: mRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 6965327 End Site(bp): 6970753 External Links: ENSG00000215021

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMP chr2 218264123 218270257 - ABL1 chr9 130713016 130887675 + ABT1 chr6 26596953 26600739 + AC004832.3 chr22 30409255 30428990 + AC006064.6 chr12 6556886 6607367 - AC007192.1 chr19 18153158 18178117 + AC010422.3 chr19 12643831 12648397 - AC011511.1 chr19 10305427 10316009 - AC093525.1 chr16 2513965 2527955 + AC245033.1 chr15 82536788 82573194 - ACAT1 chr11 108116695 108147603 + ACIN1 chr14 23058564 23095614 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTN4 chr19 38647649 38731589 + ADAR chr1 154582057 154628013 - ADCY1 chr7 45574140 45723116 + ADCY2 chr5 7396138 7830081 + ADCY3 chr2 24819169 24919839 - ADD2 chr2 70607618 70768225 - ADGRL2 chr1 81306160 81992436 + ADNP2 chr18 80109262 80147523 + AHRR chr5 271670 438291 + AL021546.1 chr12 120438198 120460006 + ALAS1 chr3 52198086 52214327 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-491-5p chr9 20716120 20716141 + hsa-miR-625-5p chr14 65471116 65471136 + hsa-miR-744-5p chr17 12081909 12081930 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC006064.5 chr12 6510275 6510522 + AC010642.2 chr19 58309727 58327248 - AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC091564.7 chr11 6610883 6616594 - AC139149.1 chr17 81514047 81527776 + AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.