exRNAdisease

Entry Detail

General Information

Database ID:

exR0438618

RNA Name:

PLCG2

RNA Type:

mRNA

Chromosome:

chr16

Starnd:

+

Coordinate:

Start Site(bp):

81739097

End Site(bp):

81962685

External Links:

ENSG00000197943

Disease Information

Disease Name:	Pediatric TB meningitis
Disease Category:	Infections
MeSH ID:	D014390
Type:	Diseases Category/Infections
Alias:	Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID:	GSE122377
Description:	Tuberculous Meningitis in Pediatric Patients [CSF]
Experimental Design:	Disease Sample Source
Case Disease Type:	Pediatric TB meningitis
Case Disease SubType:	NA
Case Sample:	Pediatric TB meningitis
Control Sample:	Lumbar Puncture Cerebrospinal Fluid
Number of Case:	12
Number of Control:	12
Number of Samples:	24

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC000093.1	chr22	19717220	19724772	+
AC005943.1	chr19	1578339	1605445	-
AC009133.6	chr16	29812261	29820092	+
AC091167.2	chr15	90249556	90272208	+
AC137834.1	chr12	57249609	57296484	-
AC138811.2	chr16	18788063	18801519	-
AC245033.1	chr15	82536788	82573194	-
ACTB	chr7	5527148	5563784	-
ADCY9	chr16	3953387	4116442	-
AGO1	chr1	35869808	35930532	+
AHCY	chr20	34280268	34311802	-
AKAP1	chr17	57085092	57121346	+
AL365205.1	chr6	41780349	41790141	+
ALDH1A2	chr15	57953424	58497866	-

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-6506-3p	chr16	15611031	15611052	-

circRNA targets:

NA

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC067930.1	chr8	143579636	143580670	+
AC067930.4	chr8	143573490	143577397	+
AC091564.7	chr11	6610883	6616594	-
AC099524.1	chr16	81738248	81767868	+
AC109460.3	chr16	28974804	28990775	+
AD000090.1	chr19	35557956	35581954	+
AL096870.2	chr14	24209646	24215987	-

Display:

Experiment Detail

GEO ID:	NA
Sample Source:	NA
Source Fraction:	NA
Platform:	NA
Method:	NA
Num of detected RNA Type:	NA
Num of detected RNAs of this Type:	NA
Sample treatment protocol:	NA
RNA Extract protocol:	NA
RNA library preparation protocol:	NA

Reference

PMID:	31434901
Title:	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Author:	Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ
Journal:	Nat Commun. 2019 Aug 21;10(1):3767.
Description:	Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.