exRNAdisease

Entry Detail

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General Information

Database ID: exR0438708 RNA Name: PLXNA1 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 126988594 End Site(bp): 127037392 External Links: ENSG00000114554

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMP chr2 218264123 218270257 - AATF chr17 36948954 37056871 + ABCA2 chr9 137007234 137028922 - ABHD4 chr14 22598237 22613215 + ACAD10 chr12 111686056 111757107 + ADAM11 chr17 44758988 44781846 + ADAM9 chr8 38996869 39105261 + ADD1 chr4 2843857 2930076 + AGBL5 chr2 27042364 27070622 + AGO2 chr8 140520156 140635633 - AL139011.2 chr1 160216800 160285130 - AL162417.1 chr9 133098121 133163914 - AL513165.2 chr9 37512547 37592469 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-96-5p chr7 129774739 129774761 - hsa-miR-7-5p chr19 4770700 4770723 + hsa-miR-182-5p chr7 129770447 129770470 - hsa-miR-205-5p chr1 209432166 209432187 + hsa-miR-185-5p chr22 20033153 20033174 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002470.2 chr22 20979462 20998121 + AC012531.1 chr12 54019910 54022589 + AC016586.1 chr19 4061615 4062749 - AC022007.1 chr3 10004048 10011209 - AC026740.1 chr5 675826 676616 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.