exRNAdisease

Entry Detail

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General Information

Database ID: exR0438966 RNA Name: PPP2R1A RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 52190048 End Site(bp): 52229518 External Links: ENSG00000105568

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF1 chr6 30571393 30597179 + ABL1 chr9 130713016 130887675 + AC006064.6 chr12 6556886 6607367 - AC008750.8 chr19 51350373 51368099 - AC010422.3 chr19 12643831 12648397 - AC245033.1 chr15 82536788 82573194 - ACADS chr12 120725774 120740008 + ACLY chr17 41866917 41930542 - ACSS1 chr20 25006230 25058980 - ACTG1 chr17 81509971 81523847 - ADAM10 chr15 58588809 58749791 - ADAMTS13 chr9 133414358 133459402 + ADAMTSL4 chr1 150549369 150560937 + ADD3 chr10 109996368 110135565 + ADH5 chr4 99070978 99088801 - AEN chr15 88621337 88632281 + AKIP1 chr11 8911139 8920084 + AKIRIN1 chr1 38991276 39006059 + AL136295.4 chr14 24180395 24190416 - ALDH18A1 chr10 95605941 95656711 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-625-5p chr14 65471116 65471136 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC008764.6 chr19 16542746 16544814 + AC016876.2 chr17 7581964 7584086 - AC019069.1 chr2 74832655 74833987 - AC020663.1 chr16 4730115 4752565 - AC026461.1 chr16 56682470 56687807 + AC079781.5 chr7 97851688 97972985 - AC132217.1 chr11 2129121 2129964 - AC245033.4 chr15 82533175 82540008 - AL021408.1 chr6 132085084 132099279 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.