exRNAdisease

Entry Detail

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General Information

Database ID: exR0439153 RNA Name: PRRC2B RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 131373636 End Site(bp): 131500197 External Links: ENSG00000130723

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAK1 chr2 69457997 69674349 - ABCB6 chr2 219209772 219218994 - ABLIM1 chr10 114431113 114768061 - AC011511.4 chr19 10315471 10320678 - AC068946.2 chr2 219209772 219222738 - AC245033.1 chr15 82536788 82573194 - ACTN4 chr19 38647649 38731589 + ACTR2 chr2 65227753 65271253 + ADIPOR1 chr1 202940826 202958572 - AFDN chr6 167826922 167972023 + AFF4 chr5 132875395 132963634 - AGAP5 chr10 73674285 73698159 - AGRN chr1 1020120 1056118 + AHCY chr20 34280268 34311802 - AHNAK2 chr14 104937244 104978374 - AKT2 chr19 40230317 40285536 - AL024498.2 chr6 10747794 10930423 + AL121594.1 chr14 35122549 35317474 + ALCAM chr3 105366909 105576900 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-31-5p chr9 21512158 21512178 - hsa-miR-147a chr9 120244985 120245004 - hsa-miR-217-5p chr2 55983020 55983042 - hsa-miR-135a-5p chr12 97563834 97563856 + hsa-miR-135b-5p chr1 205448361 205448383 - hsa-miR-483-3p chr11 2134142 2134162 - hsa-miR-520a-5p chr19 53690895 53690915 + hsa-miR-525-5p chr19 53697547 53697567 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-541-3p chr14 101064548 101064569 + hsa-miR-1286 chr22 20249145 20249165 - hsa-miR-1294 chr5 154347153 154347174 + hsa-miR-1321 chrX 85835832 85835849 + hsa-miR-5100 chr10 42997630 42997651 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005082.1 chr7 23205787 23208045 + AC022400.3 chr10 73674295 73730466 - AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.