exRNAdisease

Entry Detail

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General Information

Database ID: exR0439297 RNA Name: PTMA RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 231706895 End Site(bp): 231713541 External Links: ENSG00000187514

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC131160.1 chr3 183815568 183884889 - AL590764.2 chrX 71103987 71111575 - ACTR2 chr2 65227753 65271253 + AC006030.1 chr2 74211604 74363377 - AC008763.3 chr19 7678501 7682854 + AC120057.2 chr17 7240427 7244635 - AC092647.5 chr7 55887277 55955239 + ABHD5 chr3 43690108 43734371 + ADRA2C chr4 3766348 3768526 + ABT1 chr6 26596953 26600739 + ADNP2 chr18 80109262 80147523 + AC139530.2 chr17 81703371 81720539 + AL358113.1 chr9 69035747 69255187 + AC068946.1 chr2 219075329 219170827 - AKAP8L chr19 15380050 15419141 - AL603832.3 chr1 112702614 112711433 - ACAA2 chr18 49782164 49813953 - ALDH18A1 chr10 95605941 95656711 - AC009690.1 chr15 72284727 72375981 - AL136454.1 chr1 192716132 192716653 + ACTR1B chr2 97655939 97664044 - AGO1 chr1 35869808 35930532 + ADGRA3 chr4 22345071 22516066 - ADAM17 chr2 9488486 9556732 - ABCF3 chr3 184186023 184194012 + AC093323.1 chr4 6663396 6676755 + AKR1A1 chr1 45550543 45570049 + ADO chr10 62804720 62808479 + AC068547.1 chr2 151802651 151973949 - ABL2 chr1 179099330 179229684 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-483-5p chr11 2134181 2134202 - hsa-miR-25-5p chr7 100093610 100093630 - hsa-miR-1244 chr2 231713368 231713393 + hsa-miR-3652 chr12 103930425 103930442 + hsa-miR-3960 chr9 127785879 127785898 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005083.1 chr7 20217577 20221700 + AC007743.1 chr2 56173534 56185870 - AC007952.4 chr17 19112000 19112636 - AC008771.1 chr5 80411231 80488095 - AC009022.1 chr16 69976297 70065948 - AC012485.1 chr2 238231684 238255633 + AC012615.1 chr19 1874871 1876169 - AC016876.2 chr17 7581964 7584086 - AC018521.1 chr17 47945424 47981736 + AC026362.1 chr12 122975320 122982907 + AC061975.1 chr17 28263634 28266369 - AC068473.5 chr18 79677287 79679358 - AC092755.2 chr15 59688517 59689418 + AC116407.1 chr17 32141226 32143135 - AC245033.4 chr15 82533175 82540008 - AL121992.1 chr1 15586136 15603626 - AL137003.1 chr6 16764346 16766883 + AL137782.1 chr13 75549773 75807120 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.