Entry Detail


General Information

Database ID:exR0510731
RNA Name:AACS
RNA Type:mRNA
Chromosome:chr12
Starnd:+
Coordinate:
Start Site(bp):125065434End Site(bp):125143333
External Links:ENSG00000081760



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
NPM3
chr10
101781325
101783413
-
FGFR2
chr10
121478334
121598458
-
PDXK
chr21
43719094
43762307
+
EXOC6B
chr2
72175984
72826041
-
SIPA1L2
chr1
232397965
232561558
-
NOP14
chr4
2937933
2963406
-
ZNF579
chr19
55576774
55580848
-
MTERF4
chr2
241072169
241102332
-
EIF6
chr20
35278911
35284985
-
CITED2
chr6
139371807
139374648
-
EME1
chr17
50373220
50381483
+
PHLDA1
chr12
76025447
76033932
-
RPLP2
chr11
809965
812880
+
ZBTB44
chr11
130226677
130314917
-
KLHL21
chr1
6590724
6614607
-
TMEM259
chr19
1009648
1021179
-
RPS5
chr19
58386400
58394806
+
PCBP2
chr12
53452102
53481162
+
VCP
chr9
35056064
35072627
-
BRD9
chr5
850291
892801
-
TRIM13
chr13
49995888
50020481
+
SUPT20H
chr13
37009312
37059713
-
AIFM2
chr10
70098223
70132934
-
AL121753.1
chr20
35267885
35280043
-
OST4
chr2
27070472
27071654
-
HSP90AB1
chr6
44246166
44253888
+
BCKDK
chr16
31106107
31112791
+
AAMP
chr2
218264123
218270257
-
SELENOH
chr11
57741250
57743554
+
BUD31
chr7
99408641
99419616
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC023509.1
chr12
53441741
53467528
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.