Entry Detail


General Information

Database ID:exR0510738
RNA Name:AAK1
RNA Type:mRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):69457997End Site(bp):69674349
External Links:ENSG00000115977



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACAP2
chr3
195274745
195443044
-
ADD2
chr2
70607618
70768225
-
BANP
chr16
87949244
88077318
+
CDC42
chr1
22025511
22101360
+
CDK18
chr1
205504595
205532793
+
CFLAR
chr2
201116154
201176687
+
CHPT1
chr12
101696947
101744140
+
CNDP2
chr18
74495816
74523454
+
CTNNA1
chr5
138610967
138935034
+
GNL3
chr3
52681156
52694497
+
HCN1
chr5
45254948
45696498
-
HDLBP
chr2
241227264
241317061
-
HUWE1
chrX
53532096
53686728
-
MT-ATP6
chrMT
8527
9207
+
PAICS
chr4
56435741
56464579
+
PPP1CB
chr2
28751640
28802940
+
PRRC2B
chr9
131373636
131500197
+
PSMB2
chr1
35599541
35641526
-
PTPRZ1
chr7
121873089
122062036
+
SH2B3
chr12
111405923
111451623
+
SLCO3A1
chr15
91853708
92172435
+
SNRNP200
chr2
96274338
96321271
-
SRP14
chr15
40035690
40039181
-
SSH2
chr17
29625938
29930276
-
TRIM65
chr17
75880335
75896951
-
TRIO
chr5
14143342
14532128
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008764.6
chr19
16542746
16544814
+
AC069544.1
chr10
14877688
14878686
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.