Entry Detail


General Information

Database ID:exR0510752
RNA Name:ABCA2
RNA Type:mRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):137007234End Site(bp):137028922
External Links:ENSG00000107331



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
STK11
chr19
1177558
1228431
+
SLC36A4
chr11
93144174
93197991
-
KBTBD11
chr8
1973677
2006936
+
BMP2K
chr4
78776342
78916372
+
EXOC7
chr17
76081016
76121576
-
SMG5
chr1
156249224
156282825
-
SPECC1L
chr22
24270817
24417739
+
XXYLT1
chr3
195068284
195271159
-
NIP7
chr16
69337996
69343106
+
MYL5
chr4
673580
682033
+
RBPJ
chr4
26163455
26435131
+
REEP5
chr5
112876385
112922289
-
GANAB
chr11
62624826
62646726
-
DDX6
chr11
118747763
118791164
-
METTL26
chr16
634427
636366
-
ACAP3
chr1
1292390
1309609
-
LRP5
chr11
68312591
68449275
+
SUPT5H
chr19
39436156
39476670
+
MCM2
chr3
127598410
127622436
+
HNRNPK
chr9
83968083
83980616
-
FLNA
chrX
154348524
154374638
-
SRRM2
chr16
2752626
2772538
+
POMGNT1
chr1
46188682
46220305
-
PLXNA1
chr3
126988594
127037392
+
HDGFL3
chr15
83112738
83207823
-
YWHAQ
chr2
9583967
9630997
-
LMAN2
chr5
177331567
177351668
-
HECA
chr6
139135080
139180802
+
SEC24C
chr10
73744372
73772161
+
EXTL3
chr8
28600469
28755599
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-1286
chr22
20249145
20249165
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC067930.1
chr8
143579636
143580670
+
AD000090.1
chr19
35557956
35581954
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.