Entry Detail


General Information

Database ID:exR0510820
RNA Name:ACACA
RNA Type:mRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):37084992End Site(bp):37406836
External Links:ENSG00000278540



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
XPNPEP3
chr22
40857077
40932815
+
SORT1
chr1
109309568
109397918
-
LSM2
chr6
31797396
31806966
-
RB1CC1
chr8
52622458
52745843
-
ATXN1L
chr16
71845976
71885268
+
EIF3F
chr11
7970251
8001862
+
RPL10A
chr6
35468401
35470785
+
RAB40B
chr17
82654973
82698698
-
GANAB
chr11
62624826
62646726
-
NPC2
chr14
74476192
74494177
-
PMAIP1
chr18
59899948
59904306
+
TCF19
chr6
31158547
31167159
+
ATP2A2
chr12
110280756
110351093
+
METTL9
chr16
21597218
21657473
+
KMT2D
chr12
49018975
49059774
-
GAPDH
chr12
6534512
6538374
+
TLE3
chr15
70047790
70098176
-
SEPHS1
chr10
13317428
13348298
-
AC079447.1
chr2
99141485
99322741
+
FBXW11
chr5
171861549
172006873
-
FBRS
chr16
30658431
30670810
+
FAM126A
chr7
22889371
23014130
-
IQGAP1
chr15
90388242
90502239
+
CACHD1
chr1
64470129
64693058
+
PDE8A
chr15
84980440
85139145
+
DVL1
chr1
1335276
1349418
-
SIMC1
chr5
176238367
176345991
+
MRPL57
chr13
21176658
21179084
+
MTRNR2L8
chr11
10507894
10509186
-
DDX6
chr11
118747763
118791164
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-541-3p
chr14
101064548
101064569
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008514.1
chr5
170747047
170788650
-
AD000090.1
chr19
35557956
35581954
+
AC079601.2
chr12
42459366
42466128
+
AC138761.1
chr17
22266395
22288301
+
AP001496.2
chr18
5232876
5238526
-
MIR663AHG
chr20
26167817
26251546
-
MMP25-AS1
chr16
3037400
3059370
-
RMRP
chr9
35657751
35658018
-
RMST
chr12
97430884
97598415
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.