Entry Detail


General Information

Database ID:exR0510850
RNA Name:ACLY
RNA Type:mRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):41866917End Site(bp):41930542
External Links:ENSG00000131473



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC093155.3
chr1
86993009
87169204
+
CTCF
chr16
67562467
67639177
+
TRMT6
chr20
5937228
5950558
-
ADAMTSL4
chr1
150549369
150560937
+
PHF1
chr6
33410399
33416453
+
LY6E
chr8
143017982
143023832
+
NOLC1
chr10
102152176
102163871
+
CD276
chr15
73683966
73714514
+
HSBP1
chr16
83807978
83819737
+
INS-IGF2
chr11
2132538
2161209
-
RAB8A
chr19
16111889
16134234
+
HSPA8
chr11
123057489
123063230
-
RUVBL2
chr19
48993562
49015970
+
ACBD3
chr1
226144679
226186741
-
DCAF5
chr14
69050881
69153150
-
OAZ1
chr19
2269509
2273490
+
ZC3H13
chr13
45954465
46052759
-
RNF115
chr1
145738868
145824095
-
EEF1D
chr8
143579697
143599541
-
MTOR
chr1
11106535
11262551
-
LCOR
chr10
96832282
96995959
+
TNIP1
chr5
151029945
151093577
-
OS9
chr12
57693955
57721557
+
IGF2
chr11
2129112
2141238
-
HMGA1
chr6
34236873
34246231
+
SREBF2
chr22
41833079
41907307
+
WDR33
chr2
127701027
127811187
-
ATIC
chr2
215311956
215349773
+
EPHB4
chr7
100802565
100827523
-
GUK1
chr1
228139962
228148984
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-22-3p
chr17
1713914
1713935
-
hsa-miR-27a-3p
chr19
13836447
13836467
-
hsa-miR-324-3p
chr17
7223308
7223330
-
hsa-miR-1269a
chr4
66276890
66276911
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007952.4
chr17
19112000
19112636
-
AC019205.1
chr6
73263212
73301789
+
AL121899.1
chr20
2207217
2213151
+
AL132655.2
chr20
58817132
58817725
-
AC138761.1
chr17
22266395
22288301
+
AL355075.4
chr14
20343048
20343685
-
LINC01356
chr1
112820170
112850643
-
PURPL
chr5
27217714
27496994
+
TERC
chr3
169764520
169765060
-
TMEM161B-AS1
chr5
88268891
88439337
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.