Entry Detail


General Information

Database ID:exR0510917
RNA Name:ACVR2B
RNA Type:mRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):38453890End Site(bp):38493142
External Links:ENSG00000114739



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SF3A3
chr1
37956975
37990075
-
LSM4
chr19
18306230
18323274
-
DDX17
chr22
38483438
38507660
-
MTCH1
chr6
36968141
36986298
-
BCL6
chr3
187721377
187745725
-
TCOF1
chr5
150357629
150400308
+
LZTS2
chr10
100996618
101007836
+
PACSIN2
chr22
42835412
43015149
-
CBY1
chr22
38656636
38673854
+
ZDBF2
chr2
206274663
206314427
+
UNC45A
chr15
90930180
90954093
+
FAM111B
chr11
59107185
59127412
+
UBE3B
chr12
109477402
109536705
+
DNAAF2
chr14
49625174
49635230
-
GPAM
chr10
112149865
112215377
-
CHRFAM7A
chr15
30357766
30393849
-
SORD
chr15
45023181
45077185
+
HSPA5
chr9
125234853
125241343
-
MT-CO3
chrMT
9207
9990
+
TBC1D15
chr12
71839707
71927248
+
MYO7A
chr11
77128246
77215241
+
TUBA1B
chr12
49127782
49131397
-
HNRNPAB
chr5
178204533
178211163
+
MRPL12
chr17
81703367
81707517
+
SNRPN
chr15
24823637
24978723
+
AL138752.2
chr9
37588413
38068687
-
NT5DC2
chr3
52524385
52535054
-
ISOC1
chr5
129094749
129114028
+
SLC25A17
chr22
40769630
40819399
-
CRMP1
chr4
5748084
5893086
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-221-3p
chrX
45746180
45746202
-
hsa-miR-423-5p
chr17
30117095
30117117
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC090948.2
chr3
16339308
16339871
+
AD000090.1
chr19
35557956
35581954
+
LINC01578
chr15
92819540
92899701
+
LINC02035
chr3
122886941
122892416
+
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.