Entry Detail


General Information

Database ID:exR0510963
RNA Name:ADAMTSL4
RNA Type:mRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):150549369End Site(bp):150560937
External Links:ENSG00000143382



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BAG6
chr6
31639028
31652705
-
POLR2C
chr16
57462660
57472009
+
LMNA
chr1
156082573
156140089
+
EIF3L
chr22
37848868
37889407
+
NSD1
chr5
177133025
177300215
+
ZIC2
chr13
99981784
99986765
+
BST2
chr19
17402939
17405630
-
NENF
chr1
212432920
212446379
+
TAF1D
chr11
93729948
93784391
-
URM1
chr9
128371361
128392016
+
CNN2
chr19
1026586
1039068
+
PABPC1
chr8
100685816
100722809
-
ORC6
chr16
46689643
46698394
+
ZNF678
chr1
227563543
227677443
+
NFS1
chr20
35668052
35699355
-
FLNA
chrX
154348524
154374638
-
VPS4A
chr16
69311350
69326939
+
TIAL1
chr10
119571802
119597029
-
SMARCD2
chr17
63832081
63843065
-
ZDHHC18
chr1
26826688
26857604
+
UBE2V2
chr8
48008415
48064708
+
ANKFY1
chr17
4163821
4263995
-
FAR1
chr11
13668668
13732346
+
RANGAP1
chr22
41245611
41286251
-
SH3KBP1
chrX
19533977
19887600
-
SFPQ
chr1
35176378
35193145
-
EIF4H
chr7
74174245
74197101
+
ARF4
chr3
57571363
57598220
-
LIN28B
chr6
104936616
105083332
+
IGF2
chr11
2129112
2141238
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC132217.1
chr11
2129121
2129964
-
AP001372.2
chr11
74493366
74498533
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.