Entry Detail


General Information

Database ID:exR0510978
RNA Name:ADCY2
RNA Type:mRNA
Chromosome:chr5
Starnd:+
Coordinate:
Start Site(bp):7396138End Site(bp):7830081
External Links:ENSG00000078295



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RTN4
chr2
54972187
55112621
-
RBBP5
chr1
205086142
205122015
-
DMAC1
chr9
7796500
7888380
-
HIPK2
chr7
139561570
139777998
-
GDI2
chr10
5765223
5842132
-
TUFT1
chr1
151540305
151583583
+
ACTR1B
chr2
97655939
97664044
-
NAP1L1
chr12
76036585
76084958
-
KREMEN2
chr16
2964216
2968383
+
RASSF8
chr12
25959029
26079892
+
CTSV
chr9
97029677
97039643
-
SH3BP4
chr2
234952017
235055714
+
ZSCAN10
chr16
3088890
3099295
-
PHB2
chr12
6965327
6970753
-
ADCY5
chr3
123282296
123449758
-
SDCBP
chr8
58552924
58582859
+
CRABP1
chr15
78340353
78348225
+
HSP90AB1
chr6
44246166
44253888
+
LIN28A
chr1
26410817
26429728
+
DSG2
chr18
31498177
31549008
+
AURKAIP1
chr1
1373730
1375495
-
OGG1
chr3
9749944
9788219
+
APEH
chr3
49674014
49683971
+
GNAS
chr20
58839718
58911192
+
PSMD10
chrX
108084207
108091549
-
SF3B1
chr2
197388515
197435091
-
PANK1
chr10
89579497
89645572
-
MYL6
chr12
56158161
56163496
+
ANAPC15
chr11
72106378
72112780
-
YWHAE
chr17
1344275
1400222
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.