Entry Detail


General Information

Database ID:exR0511117
RNA Name:AKR1A1
RNA Type:mRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):45550543End Site(bp):45570049
External Links:ENSG00000117448



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
COG8
chr16
69320140
69339667
-
ATXN7L3
chr17
44191805
44200113
-
HNRNPUL1
chr19
41262496
41307787
+
SNRPB
chr20
2461634
2470853
-
ZMAT2
chr5
140698680
140706686
+
MRPL10
chr17
47823272
47831541
-
EPS15
chr1
51354263
51519266
-
FBLN1
chr22
45502238
45601135
+
EEF1G
chr11
62559596
62574086
-
SLC2A4RG
chr20
63739776
63744050
+
POU3F2
chr6
98834574
98839458
+
UBAP2L
chr1
154220179
154271510
+
PDK1
chr2
172555373
172608669
+
RNF126
chr19
647526
663233
-
MTRNR2L6
chr7
142666272
142667718
+
DR1
chr1
93345907
93369493
+
ZNF292
chr6
87152833
87265943
+
TKT
chr3
53224712
53256052
-
CLUH
chr17
2689386
2712663
-
FP565260.6
chr21
5155499
5165472
-
WDR74
chr11
62832342
62841809
-
SEC13
chr3
10293131
10321112
-
CDKN1A
chr6
36676460
36687339
+
MRPL33
chr2
27771717
27988087
+
RNF114
chr20
49936336
49953885
+
C1orf43
chr1
154206696
154220637
-
HDGF
chr1
156742109
156766925
-
NAA60
chr16
3443649
3486953
+
CBS
chr21
43053191
43076943
-
RPL3
chr22
39312882
39320389
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AD000090.1
chr19
35557956
35581954
+
AC069287.1
chr11
112967
125927
-
AL031005.1
chr1
21266082
21267251
+
AL359924.1
chr1
237862175
237928321
+
LINC01641
chr1
227393554
227431035
+
MALAT1
chr11
65497688
65506516
+
POLR2J4
chr7
43940895
44019175
-
SLX1A-SULT1A3
chr16
30193892
30204310
+
SNHG1
chr11
62851984
62855953
-
SNHG3
chr1
28505980
28510892
+
ZNF528-AS1
chr19
52388842
52397783
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.