Entry Detail


General Information

Database ID:exR0511127
RNA Name:AKT1
RNA Type:mRNA
Chromosome:chr14
Starnd:-
Coordinate:
Start Site(bp):104769349End Site(bp):104795751
External Links:ENSG00000142208



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
PPM1B
chr2
44167969
44244384
+
KEAP1
chr19
10486125
10503558
-
AC010422.3
chr19
12643831
12648397
-
FKBP1A
chr20
1368978
1393172
-
ACACA
chr17
37084992
37406836
-
TUFM
chr16
28842411
28846348
-
SCFD2
chr4
52872982
53366066
-
P4HB
chr17
81843161
81860624
-
CRELD1
chr3
9933816
9945406
+
SIGIRR
chr11
405716
417455
-
KDM4B
chr19
4969113
5153598
+
TMEM106C
chr12
47963569
47968878
+
FAT1
chr4
186587794
186726722
-
POU5F1
chr6
31164337
31180731
-
INTS5
chr11
62646848
62653302
-
ZC3H14
chr14
88562970
88627596
+
TPI1
chr12
6867119
6870948
+
CA14
chr1
150257251
150265078
+
KDELR3
chr22
38468078
38483447
+
DLG3
chrX
70444835
70505490
+
FBRSL1
chr12
132489551
132585188
+
MOV10
chr1
112673141
112700746
+
ENAH
chr1
225486835
225653142
-
EEF1A1
chr6
73515750
73523797
-
RARRES2
chr7
150338317
150341662
-
MVD
chr16
88651935
88663161
-
TUBB
chr6
30720352
30725426
+
HNRNPL
chr19
38836388
38852347
-
HPCAL1
chr2
10302889
10427617
+
PPA1
chr10
70202835
70233911
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004816.1
chr14
70809841
70815994
+
AC012313.3
chr19
58346854
58362751
-
AC067930.1
chr8
143579636
143580670
+
GSEC
chr11
126340889
126355587
-
MIR663AHG
chr20
26167817
26251546
-
PDCD4-AS1
chr10
110869868
110872233
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.