Entry Detail


General Information

Database ID:exR0511132
RNA Name:ALAS1
RNA Type:mRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):52198086End Site(bp):52214327
External Links:ENSG00000023330



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RAB28
chr4
13361354
13484365
-
SUPT6H
chr17
28662198
28702679
+
ENTPD1
chr10
95711779
95877266
+
SELENOH
chr11
57741250
57743554
+
RBM15B
chr3
51391285
51397908
+
AGO4
chr1
35808016
35857890
+
STIP1
chr11
64185272
64204543
+
RAB11B
chr19
8389981
8404434
+
RBP1
chr3
139517434
139539829
-
ATP5MG
chr11
118401606
118431496
+
RPS29
chr14
49570984
49599164
-
MRPL4
chr19
10251901
10260055
+
AP2S1
chr19
46838136
46850992
-
RPL7
chr8
73290242
73295789
-
RPL23
chr17
38847860
38853764
-
NR3C1
chr5
143277931
143435512
-
ABLIM1
chr10
114431113
114768061
-
ENO1
chr1
8861000
8879190
-
RPL37A
chr2
216498825
216579180
+
RAB1A
chr2
65070696
65130331
-
MGST1
chr12
16347142
16609259
+
CBX1
chr17
48070052
48101478
-
MYL6
chr12
56158161
56163496
+
HNRNPA0
chr5
137745651
137754363
-
ZNF207
chr17
32350117
32381886
+
PPFIBP2
chr11
7513298
7657127
+
KLHL23
chr2
169694488
169776989
+
PARVB
chr22
43999211
44172949
+
ARHGEF11
chr1
156934840
157045370
-
NDFIP2
chr13
79481124
79556075
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.