Entry Detail


General Information

Database ID:exR0511149
RNA Name:ALDH4A1
RNA Type:mRNA
Chromosome:chr1
Starnd:-
Coordinate:
Start Site(bp):18871430End Site(bp):18902724
External Links:ENSG00000159423



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DDI2
chr1
15617458
15669044
+
LIN28A
chr1
26410817
26429728
+
EIF5
chr14
103333544
103345025
+
RPL7A
chr9
133348218
133351426
+
SLC39A1
chr1
153959099
153968184
-
GRB2
chr17
75318076
75405709
-
RPL23
chr17
38847860
38853764
-
ERBB2
chr17
39687914
39730426
+
CASP7
chr10
113679162
113730907
+
METTL16
chr17
2405562
2511891
-
SERF2
chr15
43777087
43802589
+
ESPL1
chr12
53268299
53293638
+
SBF1
chr22
50445000
50475035
-
ACTB
chr7
5527148
5563784
-
OSBPL9
chr1
51577179
51798427
+
HLA-DRB1
chr6
32578769
32589848
-
EXOSC7
chr3
44975241
45036066
+
DCTN1
chr2
74361154
74392087
-
HDHD5
chr22
17137511
17165287
-
RHNO1
chr12
2876258
2889524
+
ZDHHC16
chr10
97446170
97457370
+
EIF3H
chr8
116642130
116766925
-
BCAM
chr19
44809071
44821421
+
FRAS1
chr4
78057323
78544269
+
NKTR
chr3
42600655
42648735
+
TUBA1A
chr12
49184795
49189080
-
EEF1B2
chr2
206159585
206162928
+
SIGIRR
chr11
405716
417455
-
FUS
chr16
31180110
31194871
+
CTNNBIP1
chr1
9848276
9910336
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AD000090.1
chr19
35557956
35581954
+
AL022311.1
chr22
37876148
37895563
+
LINC01641
chr1
227393554
227431035
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.