Entry Detail


General Information

Database ID:exR0511150
RNA Name:ALDH5A1
RNA Type:mRNA
Chromosome:chr6
Starnd:+
Coordinate:
Start Site(bp):24494867End Site(bp):24537207
External Links:ENSG00000112294



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
YWHAB
chr20
44885702
44908532
+
B2M
chr15
44711487
44718877
+
SLC25A6
chrX
1386152
1392113
-
MAP7D1
chr1
36155579
36180849
+
TTC19
chr17
15999784
16045015
+
EIF3E
chr8
108201216
108435333
-
FBRSL1
chr12
132489551
132585188
+
IRF2BP2
chr1
234604269
234609525
-
USP53
chr4
119212587
119295517
+
SH3GLB2
chr9
129007036
129028303
-
MYO10
chr5
16661907
16936288
-
TET3
chr2
73986404
74108176
+
STK11IP
chr2
219597857
219616451
+
NFKB2
chr10
102394110
102402524
+
MAPK12
chr22
50245450
50261716
-
ERRFI1
chr1
8004404
8026309
-
PNMA2
chr8
26504701
26514092
-
HUWE1
chrX
53532096
53686728
-
GTF2F1
chr19
6379572
6393981
-
RPS6
chr9
19375715
19380236
-
RPL37A
chr2
216498825
216579180
+
SLX1A
chr16
30193887
30197561
+
BAX
chr19
48954815
48961798
+
IGF2
chr11
2129112
2141238
-
KLC4
chr6
43040777
43075095
+
ZNF33A
chr10
38010650
38065088
+
ZNF12
chr7
6688433
6706947
-
LASP1
chr17
38869859
38921770
+
RPL13
chr16
89560657
89566828
+
FAM104B
chrX
55143102
55161310
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-129-5p
chr7
128207876
128207896
+
hsa-miR-330-5p
chr19
45639049
45639070
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC022201.2
chr2
70301451
70302072
+
AL645941.1
chr6
32970232
32970886
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.