Entry Detail


General Information

Database ID:exR0511368
RNA Name:AP3D1
RNA Type:mRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):2100988End Site(bp):2164468
External Links:ENSG00000065000



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABCA3
chr16
2275881
2340746
-
ABL1
chr9
130713016
130887675
+
AC008397.2
chr19
18207961
18255419
-
AC010422.5
chr19
12664828
12669397
-
AC138894.1
chr16
28456371
28492098
-
ACACA
chr17
37084992
37406836
-
ACOT7
chr1
6264269
6394391
-
ACSS1
chr20
25006230
25058980
-
ACTB
chr7
5527148
5563784
-
ACTN4
chr19
38647649
38731589
+
ADAM10
chr15
58588809
58749791
-
ADGRL1
chr19
14147743
14206187
-
AGAP3
chr7
151085831
151144436
+
AGPAT3
chr21
43865223
43987592
+
AL121845.3
chr20
63708864
63739103
+
AL713999.1
chr1
155169409
155187272
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-21-5p
chr17
59841273
59841294
+
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC019205.1
chr6
73263212
73301789
+
AC026362.1
chr12
122975320
122982907
+
AD000090.1
chr19
35557956
35581954
+
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.