Entry Detail


General Information

Database ID:exR0511390
RNA Name:APH1A
RNA Type:mRNA
Chromosome:chr1
Starnd:-
Coordinate:
Start Site(bp):150265399End Site(bp):150269580
External Links:ENSG00000117362



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004922.1
chr7
99325879
99394653
+
AC068946.2
chr2
219209772
219222738
-
AC087289.3
chr17
75898645
75930129
-
ACAP1
chr17
7336529
7351477
+
ADCY3
chr2
24819169
24919839
-
ADNP
chr20
50888916
50931437
-
AEN
chr15
88621337
88632281
+
AHSA1
chr14
77457870
77469472
+
AIP
chr11
67483026
67491103
+
AJUBA
chr14
22971177
22982551
-
ALDH9A1
chr1
165662216
165698863
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-29a-3p
chr7
130876748
130876769
-
hsa-miR-29b-3p
chr7
130877467
130877489
-
hsa-miR-29c-3p
chr1
207801865
207801886
-
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.