Entry Detail


General Information

Database ID:exR0511976
RNA Name:BIRC5
RNA Type:mRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):78214186End Site(bp):78225636
External Links:ENSG00000089685



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABRACL
chr6
139028745
139043302
+
AC138811.2
chr16
18788063
18801519
-
ACTB
chr7
5527148
5563784
-
ADAM8
chr10
133262420
133276868
-
AL022312.1
chr22
39504231
39504443
+
AL133352.1
chr10
100505628
100529881
-
ALDOA
chr16
30064164
30070457
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-16-5p
chr3
160404754
160404775
+
hsa-miR-29a-3p
chr7
130876748
130876769
-
hsa-miR-29b-3p
chr7
130877467
130877489
-
hsa-miR-103a-3p
chr5
168560904
168560926
-
hsa-miR-107
chr10
89592756
89592778
-
hsa-miR-195-5p
chr17
7017667
7017687
-
hsa-miR-29c-3p
chr1
207801865
207801886
-
hsa-miR-497-5p
chr17
7017979
7017999
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011447.3
chr19
20122569
20321305
-
AC016876.2
chr17
7581964
7584086
-
AC020663.1
chr16
4730115
4752565
-
AC021078.1
chr5
149494314
149504670
-
AC022167.2
chr16
8848105
8860456
+
AC115618.1
chrX
48568014
48574860
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.