Entry Detail


General Information

Database ID:exR0512494
RNA Name:CAPN1
RNA Type:mRNA
Chromosome:chr11
Starnd:+
Coordinate:
Start Site(bp):65180566End Site(bp):65212006
External Links:ENSG00000014216



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC008750.8
chr19
51350373
51368099
-
AC012254.2
chr18
47108188
47176345
-
AC027796.3
chr17
3585149
3636249
-
AC092143.1
chr16
89919165
89936092
+
AC093525.2
chr16
2496032
2520218
+
ACAA2
chr18
49782164
49813953
-
ACLY
chr17
41866917
41930542
-
ACTB
chr7
5527148
5563784
-
ADRM1
chr20
62302093
62308862
+
AGA
chr4
177430774
177442437
-
AKAP13
chr15
85380571
85749358
+
AKT1S1
chr19
49869033
49878459
-
AL133352.1
chr10
100505628
100529881
-
AL136295.5
chr14
24147548
24166452
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-423-5p
chr17
30117095
30117117
+
hsa-miR-4444
chr2
177212768
177212785
+
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.