Entry Detail


General Information

Database ID:exR0512931
RNA Name:CDK4
RNA Type:mRNA
Chromosome:chr12
Starnd:-
Coordinate:
Start Site(bp):57747727End Site(bp):57756013
External Links:ENSG00000135446



Disease Information

Disease Name:Lactation
Disease Category:Other Diseases
MeSH ID:D007774
Type:Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena
Alias:Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations



Expression Detail

GEO ID:GSE36936
Description:Gene Expression in the Human Mammary Epithelium during Initiation of Lactation.
Experimental Design:Time Series
Case Disease Type:Lactation
Case Disease SubType:NA
Case Sample:12h post delivery
Control Sample:6h post delivery
Number of Case:7
Number of Control:7
Number of Samples:14





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL1
chr9
130713016
130887675
+
AC007192.1
chr19
18153158
18178117
+
AC011462.1
chr19
41350853
41425001
+
AC104452.1
chr3
49416777
49429314
-
ACOT7
chr1
6264269
6394391
-
ACSL3
chr2
222860942
222944639
+
ACTG1
chr17
81509971
81523847
-
ADAM9
chr8
38996869
39105261
+
ADPRHL2
chr1
36088892
36093932
+
AKAP13
chr15
85380571
85749358
+
AKT1
chr14
104769349
104795751
-
AL021546.1
chr12
120438198
120460006
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-302c-3p
chr4
112648366
112648388
-
hsa-miR-4485-3p
chr11
10508277
10508296
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC022167.2
chr16
8848105
8860456
+
AC026356.1
chr12
32339368
32340724
+
AC091564.7
chr11
6610883
6616594
-
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:22649065
Title:Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans
Author:Mohammad MA, Hadsell DL, Haymond MW.
Journal:Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76.
Description:We have utilized our established model of the RNA isolated from breast milk fat globule from seven healthy, exclusively breastfeeding women from 6 h to 42 days following delivery to determine the temporal coordination of changes in gene expression in the carbohydrate metabolic processes emphasizing the lactose synthesis pathway in human mammary epithelial cell.