exRNAdisease

Entry Detail

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General Information

Database ID: exR0749523 RNA Name: hsa-miR-149-5p RNA Type: miRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 240456015 End Site(bp): 240456037 External Links: hsa-miR-149-5p

Disease Information

Disease Name: Lactation Disease Category: Other Diseases MeSH ID: D007774 Type: Phenomena and Processes Category/Reproductive and Urinary Physiological Phenomena Alias: Milk Secretion//Milk Secretions//Lactation, Prolonged//Lactations, Prolonged//Prolonged Lactation//Prolonged Lactations

Expression Detail

GEO ID: GSE75726 Description: Human milk cells and lipids conserve numerous known and novel miRNAs, some of which are differentially expressed during lactation Experimental Design: Time Series Case Disease Type: Lactation Case Disease SubType: NA Case Sample: Post-feeding, month 4 of lactation Control Sample: Post-feeding, month 2 of lactation Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AMOTL2 chr3 134355874 134375479 - CDT1 chr16 88803789 88809258 + FOXP1 chr3 70952817 71583993 - FZD5 chr2 207762598 207769906 - GALNT2 chr1 230057990 230282122 + GNPTAB chr12 101745499 101830959 - ITGA11 chr15 68296532 68432163 - ITGA5 chr12 54395261 54419266 - MAP3K3 chr17 63622415 63696303 + MLLT1 chr19 6210381 6279975 - PHLPP2 chr16 71637835 71724701 - RAB31 chr18 9708275 9862551 + RCC2 chr1 17406760 17439677 - SLC6A6 chr3 14402576 14489349 + SMG5 chr1 156249224 156282825 - WDR36 chr5 111091716 111130502 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000241 chr10 70847874 70856944 + hsa_circ_0000907 chr19 17212469 17213367 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL035458.2 chr20 34234840 34281173 - AL160006.1 chr1 110058340 110062555 + MALAT1 chr11 65497688 65506516 + MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + SNHG8 chr4 118278709 118285316 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 27074017 Title: Human Milk Cells and Lipids Conserve Numerous Known and Novel miRNAs, Some of Which Are Differentially Expressed during Lactation Author: Alsaweed M, Lai CT, Hartmann PE, Geddes DT, Kakulas F Journal: PLoS One. 2016 Apr 13;11(4):e0152610. Description: We used deep sequencing to profile miRNAs in the cell and lipid fractions of HM obtained post-feeding from 10 lactating women in months 2, 4, and 6 postpartum.